Coding
Part:BBa_K3846120
Designed by: Marcel Arvid Zimmeck Group: iGEM21_Hamburg (2021-10-15)
Hydroxymethylglutaryl-CoA synthase (HMGCS1) - MevT Pathway (phytobrick)
This phyto brick features the codon-optimised coding sequence of Hydroxymethylglutaryl-CoA synthase (HMGCS1) from Homo sapiens. This enzyme the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.
5' fusion site: TTCG
3' fusion site: GCTT
ttcg - gctt
Sequence and Features
Assembly Compatibility:
- 10COMPATIBLE WITH RFC[10]
- 12COMPATIBLE WITH RFC[12]
- 21COMPATIBLE WITH RFC[21]
- 23COMPATIBLE WITH RFC[23]
- 25COMPATIBLE WITH RFC[25]
- 1000COMPATIBLE WITH RFC[1000]
[edit]
Categories
Parameters
None |